Neuronal subtype specification in the cerebral cortex

被引：1191

作者：

Molyneaux, Bradley J.

Arlotta, Paola

Menezes, Joao R. L.

Macklis, Jeffrey D. ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, MGH HMS Ctr Nervous Syst Repair, Dept Neurosurg,Program Neurosci,Med Sch, Boston, MA 02115 USA

[2] Harvard Univ, Massachusetts Gen Hosp, MGH HMS Ctr Nervous Syst Repair, Dept Neurol,Program Neurosci,Med Sch, Boston, MA 02115 USA

[3] Harvard Univ, Stem Cell Inst, Boston, MA 02114 USA

[4] Univ Fed Rio de Janeiro, Lab Neuroanat Celular, Dept Anat, Inst Ciencias Biomed,Programa Ciencias Morfol, Rio De Janeiro, Brazil

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 06期

关键词：

D O I：

10.1038/nrn2151

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In recent years, tremendous progress has been made in understanding the mechanisms underlying the specification of projection neurons within the mammalian neocortex. New experimental approaches have made it possible to identify progenitors and study the lineage relationships of different neocortical projection neurons. An expanding set of genes with layer and neuronal subtype specificity have been identified within the neocortex, and their function during projection neuron development is starting to be elucidated. Here, we assess recent data regarding the nature of neocortical progenitors, review the roles of individual genes in projection neuron specification and discuss the implications for progenitor plasticity.

引用

页码：427 / 437

页数：11

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