Lessons on longevity from budding yeast

被引：320

作者：

Kaeberlein, Matt ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Guangdong Med Coll, Inst Aging Res, Dongguan 523808, Peoples R China

来源：

NATURE | 2010年 / 464卷 / 7288期

基金：

美国国家卫生研究院;

关键词：

LIFE-SPAN EXTENSION; SACCHAROMYCES-CEREVISIAE; CALORIE RESTRICTION; DIETARY RESTRICTION; SCHIZOSACCHAROMYCES-POMBE; DAUGHTER CELLS; RESVERATROL; SIR2; AGE; TOR;

D O I：

10.1038/nature08981

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The past decade has seen fundamental advances in our understanding of the ageing process and raised optimism that interventions to slow ageing may be on the horizon. Studies of budding yeast have made immense contributions to this progress. Yeast longevity factors have now been shown to modulate ageing in invertebrate and mammalian models, and studies of yeast have resulted in some of the best candidates for anti-ageing drugs currently in development. The first interventions to slow human ageing may spring from the humble yeast.

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收藏

页码：513 / 519

页数：7

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