Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists

被引：40

作者：

Bonnefous, C

Vernier, JM

Hutchinson, JH

Chung, J

Reyes-Manalo, G

Kamenecka, T

机构：

[1] Merck Res Labs, Dept Med Chem, San Diego, CA 92121 USA

[2] Merck Res Labs, Dept Neuropharmacol, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 04期

关键词：

mGluR5; amides; CNS disorders;

D O I：

10.1016/j.bmcl.2004.11.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The mGlu5 receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amides as small molecules mGluR5 antagonists. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1197 / 1200

页数：4

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