Analysis of lysergic acid diethylamide:: comparison of capillary electrophoresis with laser-induced fluorescence (CE-LIF) with conventional techniques

被引:15
作者
Frost, M [1 ]
Köhler, H [1 ]
机构
[1] Westfalische Wilhelms Universitat, Inst Rechtsmed, D-48149 Munster, Germany
关键词
forensic science; LSD; capillary electrophoresis; laser-induced fluorescence;
D O I
10.1016/S0379-0738(98)00017-6
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
The increasing use of the potent hallucinogenic drug D-lysergic acid diethylamide (LSD) makes the application of highly sensitive analytical techniques necessary. For an effective analysis of biological specimens a limit of detection in the sub-ng/ml range is required. Using capillary electrophoresis (CE) with laser-induced fluorescence detection it was possible to determine 0.1-0.2 ng LSD/ml blood. The conventionally used immunoassays and gas and high-performance liquid chromatographic methods have cut-off values and limit of detection, respectively, in the same range. Only tandem mass spectrometry techniques can be more sensitive. Therefore, CE can be considered a good complementary method to conventional immunological and chromatographic techniques for the forensic analysis of biofluids. (C) 1998 Elsevier Science Ireland Ltd.
引用
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页码:213 / 218
页数:6
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