Syntheses of bis(3′-indolyl)-2(1H)-pyrazinones

The syntheses of 3,6-bis(3'-indolyl)-2(1H)-pyrazinone and 3,5-bis(3'-indolyl)-2( 1H)-pyrazinone were described. Syntheses of 3,6-bis(3 '-indolyl)2(1H)-pyrazinone proceeded through the condensation of N-Boc-indolylglycine with indol-3-yl-N-methyl-O-methoxyglycinamide, and followed by reduction with LiAlH4 and cyclization of the resulting bisindolyl aldehyde-amine. 3,5-Bis(3'-indolyl)-2(1H)-pyrazinone was synthesized by cyclization of bisindolyl ketone amine in excess of ammonia under pressure.