Syntheses of bis(3′-indolyl)-2(1H)-pyrazinones

被引:32
作者
Jiang, B [1 ]
Gu, XH [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
关键词
bisinoble alkaloid; dipeptidyl aldehyde; bisindolyl ketone amine; cyclization;
D O I
10.3987/COM-00-8887
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The syntheses of 3,6-bis(3'-indolyl)-2(1H)-pyrazinone and 3,5-bis(3'-indolyl)-2( 1H)-pyrazinone were described. Syntheses of 3,6-bis(3 '-indolyl)2(1H)-pyrazinone proceeded through the condensation of N-Boc-indolylglycine with indol-3-yl-N-methyl-O-methoxyglycinamide, and followed by reduction with LiAlH4 and cyclization of the resulting bisindolyl aldehyde-amine. 3,5-Bis(3'-indolyl)-2(1H)-pyrazinone was synthesized by cyclization of bisindolyl ketone amine in excess of ammonia under pressure.
引用
收藏
页码:1559 / 1568
页数:10
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