Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
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作者:
LeibundGut-Landmann, Salome
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
LeibundGut-Landmann, Salome
Gross, Olaf
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Gross, Olaf
Robinson, Matthew J.
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Robinson, Matthew J.
Osorio, Fabiola
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Osorio, Fabiola
Slack, Emma C.
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Slack, Emma C.
Tsoni, S. Vicky
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Tsoni, S. Vicky
Schweighoffer, Edina
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Schweighoffer, Edina
Tybulewicz, Victor
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Tybulewicz, Victor
Brown, Gordon D.
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Brown, Gordon D.
Ruland, Juergen
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机构:London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Ruland, Juergen
Sousa, Caetano Reis e
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London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, EnglandLondon Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Sousa, Caetano Reis e
[1
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机构:
[1] London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs). However, whether this pathway promotes full DC activation remains unclear. Here we show that dectin-1-Syk-CARD9 signaling induced DC maturation and the secretion of proinflammatory cytokines, including IL-6, tumor necrosis factor and IL-23, but little IL-12. Dectin-1-activated DCs 'instructed' the differentiation of CD4+ IL-17-producing effector T cells (TH-17 cells) in vitro, and a dectin-1 agonist acted as an adjuvant promoting the differentiation of TH-17 and T helper type 1 cells in vivo. Infection with Candida albicans induced CARD9-dependent TH-17 responses to the organism. Our data indicate that signaling through Syk and CARD9 can couple innate to adaptive immunity independently of Toll-like receptor signals and that CARD9 is required for the development of TH-17 responses to some pathogens.
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Rivera, Amariliz
Ro, Grace
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Ro, Grace
Van Epps, Heather L.
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Van Epps, Heather L.
Simpson, Tyler
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Simpson, Tyler
Leiner, Ingrid
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Leiner, Ingrid
Sant'Angelo, Derek B.
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Sant'Angelo, Derek B.
Pamer, Eric G.
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
机构:
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Rivera, Amariliz
Ro, Grace
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机构:
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Ro, Grace
Van Epps, Heather L.
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机构:
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Van Epps, Heather L.
Simpson, Tyler
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Simpson, Tyler
Leiner, Ingrid
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Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Leiner, Ingrid
Sant'Angelo, Derek B.
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机构:
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA
Sant'Angelo, Derek B.
Pamer, Eric G.
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机构:
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Infect Dis Serv, Program Immunol, New York, NY 10021 USA