Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

被引:36
作者
Mini, R
Figura, N
D'Ambrosio, C
Braconi, D
Bernardini, G
Di Simplicio, F
Lenzi, C
Nuti, R
Trabalzini, L
Martelli, P
Bovalini, L
Scaloni, A
Santucci, A
机构
[1] Univ Siena, Dipartimento Biol Mol, I-53100 Siena, Italy
[2] Univ Siena, Dipartimento Med Interna Sci Endocrinometab & Bio, I-53100 Siena, Italy
[3] CNR, ISPAAM, Proteom & Mass Spectrometry Lab, Naples, Italy
[4] Univ Siena, Policlin Le Scotte, Dipartimento Med Clin & Sci Immunol, I-53100 Siena, Italy
关键词
Helicobacter pylori; immunoglobulins; immunoproteome;
D O I
10.1002/pmic.200401094
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria has been suggested although still controversial. The aim of the present study was to establish a relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)-, IgG-, and IgE-mediated immune-responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA- and IgE-mediated immune response against antioxidative bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases pathogenesis is discussed.
引用
收藏
页码:777 / 787
页数:11
相关论文
共 70 条
[1]   Incidence of anti-Helicobacter pylori and anti-CagA antibodies in rosacea patients [J].
Argenziano, G ;
Donnarumma, G ;
Iovene, MR ;
Arnese, P ;
Baldassarre, MA ;
Baroni, A .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2003, 42 (08) :601-604
[2]   Helicobacter gastroduodenitis: A serious infectious disease - Antibiotic treatment may prevent deaths in the decades ahead [J].
Axon, A ;
Forman, D .
BRITISH MEDICAL JOURNAL, 1997, 314 (7092) :1430-1431
[3]   Effect of treatment of Helicobacter pylori infection on rosacea [J].
Bamford, JTM ;
Tilden, RL ;
Blankush, JL ;
Gangeness, DE .
ARCHIVES OF DERMATOLOGY, 1999, 135 (06) :659-663
[4]   Helicobacter pylori virulence and genetic geography [J].
Covacci, A ;
Telford, JL ;
Del Giudice, G ;
Parsonnet, J ;
Rappuoli, R .
SCIENCE, 1999, 284 (5418) :1328-1333
[5]   MUCOSAL IGA RECOGNITION OF HELICOBACTER-PYLORI 120-KDA PROTEIN, PEPTIC-ULCERATION, AND GASTRIC PATHOLOGY [J].
CRABTREE, JE ;
TAYLOR, JD ;
WYATT, JI ;
HEATLEY, RV ;
SHALLCROSS, TM ;
TOMPKINS, DS ;
RATHBONE, BJ .
LANCET, 1991, 338 (8763) :332-335
[6]   Gastric mucosal inflammatory responses to Helicobacter pylori [J].
Crabtree, JE .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 1996, 10 :29-37
[7]  
CZARNETZKI BM, 1986, URTICARIA, P32
[8]   Helicobacter pylori infection is markedly increased in patients with autoimmune atrophic thyroiditis [J].
de Luis, DA ;
Varela, C ;
de La Calle, H ;
Cantón, R ;
de Argila, CM ;
San Roman, AL ;
Boixeda, D .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1998, 26 (04) :259-263
[9]   Identification of genes regulated by prolonged acid exposure in Helicobacter pylori [J].
Dong, QJ ;
Hyde, D ;
Herra, C ;
Kean, C ;
Murphy, P ;
O'Morain, CA ;
Buckley, M .
FEMS MICROBIOLOGY LETTERS, 2001, 196 (02) :245-249
[10]   UREASE-ASSOCIATED HEAT-SHOCK PROTEIN OF HELICOBACTER-PYLORI [J].
EVANS, DJ ;
EVANS, DG ;
ENGSTRAND, L ;
GRAHAM, DY .
INFECTION AND IMMUNITY, 1992, 60 (05) :2125-2127