The total synthesis of psymberin

被引：53

作者：

Huang, Xianhai ^{[1
]}

Shao, Ning ^{[1
]}

Palani, Anandan ^{[1
]}

Aslanian, Robert ^{[1
]}

Buevich, Alexei ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Dept Chem Res, Kenilworth, NJ 07033 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 13期

关键词：

D O I：

10.1021/ol071068n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of a new member of the pederin family of natural products, psymberin 1, was accomplished. Using a recently reported novel and efficient PhI(OAc)(2) mediated oxidative entry to 2-(N-acylaminal)-substituted tetrahydropyrans as the key step, this total synthesis was executed in a convergent and efficient manner. The longest linear sequence of this synthesis was 22 steps starting from known 6.

引用

页码：2597 / 2600

页数：4

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