Inflammatory Inhibitory Activity of Sesquiterpenoids from Atractylodes macrocephala Rhizomes

被引：95

作者：

Hoang, Le Son ^{[1
]}

Tran, Manh Hung ^{[1
]}

Lee, Joo-Sang ^{[1
]}

Quynh Mai Thi Ngo ^{[1
]}

Woo, Mi Hee ^{[1
]}

Min, Byung Sun ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 712702, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2016年 / 64卷 / 05期

关键词：

Atractylodes macrocephala; Compositae; sesquiterpenoid; anti-inflammatory activity; RAW264.7; cell; CIRCULAR-DICHROISM; NO PRODUCTION; FERULIC ACID; CONSTITUENTS; PRINCIPLES;

D O I：

10.1248/cpb.c15-00805

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Three new sesquiterpenoids, 13-hydroxyl-atractylenolide II (1), 4-ketone-atractylenolide III (2), and eudesm-4(15)-ene-7 beta,11-diol (3), along with eleven known compounds (4-14), were isolated from the rhizomes of Atractylodes macrocephala. The structures and relative configurations of 1-3 were determined by analysis of the spectroscopic data, and the absolute configurations of 1 and 2 were assigned by circular dichroism technique. The anti-inflammatory activities of these isolates were evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cells; compounds 4, 7, and 8 exhibited moderate efficacy with IC50 values of 48.6+/-0.5, 46.4+/-3.2, and 32.3+/-2.9 mu M, respectively.

引用

页码：507 / 511

页数：5

共 33 条

[1]

BEECHAM AF, 1972, TETRAHEDRON LETT, P1669

[2]

Absolute Configuration of Eremophilane Sesquiterpenes from Petasites hybridus: Comparison of Experimental and Calculated Circular Dichroism Spectra [J].

Bodensieck, Antje ;

Fabian, Walter M. F. ;

Kunert, Olaf ;

Belaj, Ferdinand ;

Jahangir, Sajid ;

Schuehly, Wolfgang ;

Bauer, Rudolf .

CHIRALITY, 2010, 22 (03) :308-319

[3]

A sesquiterpene lactam from Artractylodes macrocephala [J].

Chen, ZL ;

Cao, WY ;

Zhou, GX ;

Wichtl, M .

PHYTOCHEMISTRY, 1997, 45 (04) :765-767

[4]

New Nitrogen-Containing Sesquiterpenoids from the Taiwanese Soft Coral Cespitularia taeniata MAY [J].

Cheng, Yuan-Bin ;

Chen, Ching-Yeu ;

Kuo, Yao-Haur ;

Shen, Ya-Ching .

CHEMISTRY & BIODIVERSITY, 2009, 6 (08) :1266-1272

[5]

Anti-inflammatory components isolated from Atractylodes macrocephala Koidz [J].

Dong, Haiyan ;

He, Langchong ;

Huang, Meng ;

Dong, Yalin .

NATURAL PRODUCT RESEARCH, 2008, 22 (16) :1418-1427

[6]

A new cytotoxic prenylated dihydrobenzofuran derivative and other chemical constituents from the rhizomes of Atractylodes lancea DC [J].

Duan, Jin-ao ;

Wang, Liuying ;

Qian, Shihui ;

Su, Shulan ;

Tang, Yuping .

ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (08) :965-969

[7]

Natural sesquiterpenoids [J].

Fraga, Braulio M. .

NATURAL PRODUCT REPORTS, 2009, 26 (09) :1125-1155

[8]

Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats [J].

Gandhi, Gopalsamy Rajiv ;

Ignacimuthu, Savarimuthu ;

Paulraj, Michael Gabriel ;

Sasikumar, Ponnusamy .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2011, 670 (2-3) :623-631

[9]

HIKINO H, 1964, CHEM PHARM BULL, V12, P755

[10]

New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional cytochrome P450-dependent monooxygenase [J].

Humphreys, JM ;

Hemm, MR ;

Chapple, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :10045-10050

← 1 2 3 4 →