The Holy Grail of Organocatalysis: Intermolecular α-Alkylation of Aldehydes

被引:58
作者
Alba, Andrea-Nekane [1 ]
Viciano, Monica [1 ]
Rios, Ramon [1 ]
机构
[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain
关键词
alkylation; carbocations; enantioselectivity; organocatalysis; synthetic methods; CARBOXYLIC-ACID DERIVATIVES; ASYMMETRIC ALKYLATION; ENANTIOSELECTIVE CYCLOPROPANATION; ALPHA; BETA-UNSATURATED ALDEHYDES; 3-(1-ARYLSULFONYLALKYL) INDOLES; CHIRAL CYCLOPROPANES; CATALYSIS; AMINOCATALYSIS; CHEMISTRY; SOLVENT;
D O I
10.1002/cctc.200900196
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
This is the cup of a chemist: Organocatalytic intermolecular a-alkylation has been accomplished. The groups of Melchiorre and Cozzi have recently reported the realization of this long-time goal in organocatalysis, by the crucial use of stabilized carbocations. Alkylated products are obtained in good yields and with moderate to good enantioselectivities. © 2009 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim.
引用
收藏
页码:437 / 439
页数:3
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