Radical dearomatising spirocyclisations onto the C-2 position of benzofuran and indole

被引：47

作者：

Kyei, AS ^{[1
]}

Tchabanenko, K ^{[1
]}

Baldwin, JE ^{[1
]}

Adlington, RM ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 48期

关键词：

alkyl radical; vinyl radical; aryl radical; spirocyclisation; benzofuran; indole; spirocycle;

D O I：

10.1016/j.tetlet.2004.09.148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spirolactams were obtained via an intramolecular radical ipso-type spirocyclisation in benzofuran and indole systems. Alkyl, vinyl and aryl radicals, tethered at the C-2 position of the heterocycle underwent radical cyclisation to produce novel tricyclic partially dearomatised heterocycles in moderate yields. Fragmentation of the furan ring was observed subsequent to spirocyclisation of a vinyl radical onto a benzofuran. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8931 / 8934

页数：4

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