Aryl radical cyclisation onto pyrroles: a divergent synthesis of spiropyrrolidinyloxindoles and pyrroloquinolines

被引:77
作者
Escolano, C [1 ]
Jones, K [1 ]
机构
[1] Kingston Univ, Sch Chem & Pharmaceut Sci, Kingston upon Thames KT1 2EE, Surrey, England
关键词
D O I
10.1016/S0040-4039(00)01588-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The regiochemistry of cyclisation of an aryl radical on to a pyrrole is shown to depend on the N-substituent of the pyrrole. Changing this substituent allows the selective synthesis of either the spiropyrrolidinyloxindole or the pyrrolo[3,2-c]quinoline skeleton. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:8951 / 8955
页数:5
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