Chromatin remodelling during development

被引：827

作者：

Ho, Lena ^{[1
]}

Crabtree, Gerald R. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Beckman Ctr, Stanford, CA 94305 USA

来源：

NATURE | 2010年 / 463卷 / 7280期

基金：

美国国家卫生研究院;

关键词：

CELL SELF-RENEWAL; HISTONE VARIANT H2A.Z; GENE-EXPRESSION; COMPLEX; TRANSCRIPTION; COMPONENT; PROTEIN; SUBUNIT; PLURIPOTENCY; FAMILY;

D O I：

10.1038/nature08911

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in development and in response to extracellular cues. In addition to DNA methylation and histone modification, ATP-dependent enzymes that remodel chromatin are important controllers of chromatin structure and assembly, and are major contributors to the dynamic nature of chromatin. Evidence is emerging that these chromatin-remodelling enzymes have instructive and programmatic roles during development. Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells.

引用

页码：474 / 484

页数：11

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