Efficient synthesis and resolution of pyrrolizidines

被引：44

作者：

de Figueiredo, Renata Marcia

Froehlich, Roland

Christmann, Mathias

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

[2] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 16期

关键词：

antitumor agents; chiral resolution; lactonization; natural products; organocatalysis;

D O I：

10.1002/anie.200605035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In only two steps the commercially available maleimide 1 is converted into the key pyrrolizidine carboxylic acid unit (2) of the telomerase inhibitor UCS1025A. A kinetic resolution through an enantioselective oxa-Michael lactonization and trituration of the resulting scalemic mixture allow for a virtually quantitative separation of a racemate into the enantiomers. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

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页码：2883 / 2886

页数：4

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