Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate

被引:115
作者
Choi, Seok Ki [1 ]
Thomas, Thommey [1 ]
Li, Ming-Hsin [1 ]
Kotlyar, Alina [1 ]
Desai, Ankur [1 ]
Baker, James R., Jr. [1 ]
机构
[1] Univ Michigan, Sch Med, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
CANCER-THERAPY; ANTICANCER DRUGS; ACID; NANOPARTICLES; NANODEVICE; MOLECULES; DIAGNOSIS;
D O I
10.1039/b927215c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report the synthesis and in vitro evaluation of folate receptor-targeted nanoconjugate that releases its therapeutic payload via a photochemical mechanism.
引用
收藏
页码:2632 / 2634
页数:3
相关论文
共 26 条
[1]   Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles [J].
Agasti, Sarit S. ;
Chompoosor, Apiwat ;
You, Chang-Cheng ;
Ghosh, Partha ;
Kim, Chae Kyu ;
Rotello, Vincent M. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (16) :5728-+
[2]   Nanoparticles in cancer therapy and diagnosis [J].
Brigger, I ;
Dubernet, C ;
Couvreur, P .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651
[3]   PHOTOINDUCED REACTIONS OF ANTHRAQUINONE ANTITUMOR AGENTS WITH PEPTIDES AND NUCLEIC-ACID BASES - AN ELECTRON-SPIN RESONANCE AND SPIN TRAPPING STUDY [J].
CARMICHAEL, AJ ;
RIESZ, P .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 237 (02) :433-444
[4]   INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA - THE CRYSTAL-STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG) [J].
CIRILLI, M ;
BACHECHI, F ;
UGHETTO, G ;
COLONNA, FP ;
CAPOBIANCO, ML .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 230 (03) :878-889
[5]   Blood-vessel closure using photosensitizers engineered for two-photon excitation [J].
Collins, Hazel A. ;
Khurana, Mamta ;
Moriyama, Eduardo H. ;
Mariampillai, Adrian ;
Dahlstedt, Emma ;
Balaz, Milan ;
Kuimova, Marina K. ;
Drobizhev, Mikhail ;
Yang, Victor X. D. ;
Phillips, David ;
Rebane, Aleksander ;
Wilson, Brian C. ;
Anderson, Harry L. .
NATURE PHOTONICS, 2008, 2 (07) :420-424
[6]   Folic acid-mediated targeting of cowpea mosaic virus particles to tumor cells [J].
Destito, Giuseppe ;
Yeh, Robert ;
Rae, Chris S. ;
Finn, M. G. ;
Manchester, Marianne .
CHEMISTRY & BIOLOGY, 2007, 14 (10) :1152-1162
[7]   Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs [J].
Dubowchik, GM ;
Walker, MA .
PHARMACOLOGY & THERAPEUTICS, 1999, 83 (02) :67-123
[8]   Soluble single-walled carbon nanotubes as longboat delivery systems for Platinum(IV) anticancer drug design [J].
Feazell, Rodney P. ;
Nakayama-Ratchford, Nozomi ;
Dai, Hongjie ;
Lippard, Stephen J. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (27) :8438-+
[9]   Brominated 7-hydroxycoumarin-4-ylmethyls: Photolabile protecting groups with biologically useful cross-sections for two photon photolysis [J].
Furuta, T ;
Wang, SSH ;
Dantzker, JL ;
Dore, TM ;
Bybee, WJ ;
Callaway, EM ;
Denk, W ;
Tsien, RY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1193-1200
[10]  
Gagey N., 2007, ANGEW CHEM, V119, P2519