Toxic epidermal necrolysis

被引：39

作者：

Wolkenstein, P ^{[1
]}

Revuz, J ^{[1
]}

机构：

[1] Univ Paris 12, Hop Henri Mondor, Dept Dermatol, F-94010 Creteil, France

来源：

DERMATOLOGIC CLINICS | 2000年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0733-8635(05)70196-0

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2) the mechanism leading to epidermal necrolysis seems to be a cell-mediated cytotoxic reaction. The treatment remains symptomatic.

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收藏

页码：485 / +

页数：12

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