Toxic epidermal necrolysis

被引：39

作者：

Wolkenstein, P ^{[1
]}

Revuz, J ^{[1
]}

机构：

[1] Univ Paris 12, Hop Henri Mondor, Dept Dermatol, F-94010 Creteil, France

来源：

DERMATOLOGIC CLINICS | 2000年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0733-8635(05)70196-0

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Toxic epidermal necrolysis (TEN) is a rare but life-threatening adverse drug reaction. Implicated drugs are sulfonamides, anticonvulsants, allopurinol, and pyrazolone derivatives. Recently, advances in pathogenesis have been made in two directions. It is now known that (1) most patients with TEN have an abnormal metabolism to the culprit drug; and (2) the mechanism leading to epidermal necrolysis seems to be a cell-mediated cytotoxic reaction. The treatment remains symptomatic.

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页码：485 / +

页数：12

相关论文

共 91 条

[41] Toxic epidermal necrolysis syndrome: Mortality rate reduced with early referral to Regional Burn Center [J].

McGee, T ;

Munster, A .

PLASTIC AND RECONSTRUCTIVE SURGERY, 1998, 102 (04) :1018-1022

[42] STAPHYLOCOCCAL SCALDED-SKIN SYNDROME - DEVELOPMENT OF AN EXPERIMENTAL MODEL [J].

MELISH, ME ;

GLASGOW, LA .

NEW ENGLAND JOURNAL OF MEDICINE, 1970, 282 (20) :1114-+

[43] Vulvovaginal involvement in toxic epidermal necrolysis: A retrospective study of 40 cases [J].

Meneux, E ;

Wolkenstein, P ;

Haddad, B ;

Roujeau, JC ;

Revuz, J ;

Paniel, BJ .

OBSTETRICS AND GYNECOLOGY, 1998, 91 (02) :283-287

[44] LYMPHOCYTE SUBSETS AND LANGERHANS CELLS IN TOXIC EPIDERMAL NECROLYSIS - REPORT OF A CASE [J].

MEROT, Y ;

GRAVALLESE, E ;

GUILLEN, FJ ;

MURPHY, GF .

ARCHIVES OF DERMATOLOGY, 1986, 122 (04) :455-458

[45] T-CELL SUBSETS IN DRUG-INDUCED TOXIC EPIDERMAL NECROLYSIS - POSSIBLE PATHOGENIC MECHANISM INDUCED BY CD8-POSITIVE T-CELLS [J].

MIYAUCHI, H ;

HOSOKAWA, H ;

AKAEDA, T ;

IBA, H ;

ASADA, Y .

ARCHIVES OF DERMATOLOGY, 1991, 127 (06) :851-855

[46] PARANEOPLASTIC PEMPHIGUS [J].

MUTASIM, DF ;

PELC, NJ ;

ANHALT, GJ .

DERMATOLOGIC CLINICS, 1993, 11 (03) :473-481

[47] INCIDENCE OF TOXIC EPIDERMAL NECROLYSIS IN ITALY [J].

NALDI, L ;

LOCATI, F ;

MARCHESI, L ;

CAINELLI, T .

ARCHIVES OF DERMATOLOGY, 1990, 126 (08) :1103-1104

[48]

PANCIERA DL, 1987, J AM VET MED ASSOC, V191, P1125

[49]

Paquet P, 1998, EUR J CLIN INVEST, V28, P528

[50] MACROPHAGES AND TUMOR-NECROSIS-FACTOR-ALPHA IN TOXIC EPIDERMAL NECROLYSIS [J].

PAQUET, P ;

NIKKELS, A ;

ARRESE, JE ;

VANDERKELEN, A ;

PIERARD, GE .

ARCHIVES OF DERMATOLOGY, 1994, 130 (05) :605-608

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