Valence Tautomerism in Titanium Enolates: Catalytic Radical Haloalkylation and Application in the Total Synthesis of Neodysidenin

被引：102

作者：

Beaumont, Stephane ^{[1
]}

Ilardi, Elizabeth A. ^{[1
]}

Monroe, Lucas R. ^{[1
]}

Zakarian, Armen ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 05期

基金：

美国国家科学基金会;

关键词：

KETENE SILYL ACETALS; BARBAMIDE BIOSYNTHESIS; DYSIDEA-HERBACEA; HALOPEROXIDASES; DERIVATIVES; ADDITIONS; PEPTIDES; ETHERS;

D O I：

10.1021/ja910154f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A direct ruthenium-catalyzed radical chloroalkylation of N-acyl oxazolidinones capitalizing on valence tautomerism of titanium enolates has been developed. The chloroalkylation method served as the centerpiece in the enantioselective total synthesis of trichloroleucine-derived marine natural product neodysidenin.

引用

页码：1482 / +

页数：4

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