Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography

被引：92

作者：

Carlucci, G

Palumbo, G

Mazzeo, P

Quaglia, MG

机构：

[1] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67010 Coppito, Laquila, Italy

[2] Univ Aquila, Dipartimento Med Interna & Sanita Pubbl, I-67010 Coppito, Laquila, Italy

[3] Univ Roma La Sapienza, Dipartimento Studi Farmaceut, I-00185 Rome, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 01期

关键词：

HPLC; losartan potassium; hydrochlorothiazide; simultaneous determination; tablets;

D O I：

10.1016/S0731-7085(00)00268-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration lange 3.0-7.0 mu g ml(-1) for losartan and 0.5-2.0 mu g ml(-1) for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 0.08 mu g ml(-1) for losartan and 0.05 mu g ml(-1) for hydrochlorothiazide. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：185 / 189

页数：5

相关论文

共 32 条

[1] SIMULTANEOUS DETERMINATION OF ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE IN TABLETS BY DERIVATIVE UV SPECTROPHOTOMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

CARLUCCI, G ;

DIGIUSEPPE, E ;

MAZZEO, P .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1993, 93 (1-3) :245-248

[2]

CIERI UR, 1994, J AOAC INT, V77, P1104

[3] A study of losartan, alone or with hydrochlorothiazide vs nifedipine GITS in elderly patients with diastolic hypertension [J].

Conlin, PR ;

Elkins, M ;

Liss, C ;

Vrecenak, AJ ;

Barr, E ;

Edelman, JM .

JOURNAL OF HUMAN HYPERTENSION, 1998, 12 (10) :693-699

[4] Efficacy and safety of losartan in the treatment of hypertension in renal transplant recipients [J].

Del Castillo, D ;

Campistol, JM ;

Guirado, L ;

Capdevilla, L ;

Martínez, JG ;

Pereira, P ;

Bravo, J ;

Pérez, R .

KIDNEY INTERNATIONAL, 1998, 54 :S135-S139

[5]

Deppeler H.P., 1981, Analytical Profiles of Drug Substances, V10, P405, DOI [10.1016/S0099-5428(08)60646-2, DOI 10.1016/S0099-5428(08)60646-2]

[6] THE DISCOVERY OF DUP-753, A POTENT, ORALLY ACTIVE NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST [J].

DUNCIA, JV ;

CARINI, DJ ;

CHIU, AT ;

JOHNSON, AL ;

PRICE, WA ;

WONG, PC ;

WEXLER, RR ;

TIMMERMANS, PBMWM .

MEDICINAL RESEARCH REVIEWS, 1992, 12 (02) :149-191

[7] SIMULTANEOUS DETERMINATION OF ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE BY FIRST-DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

ELWALILY, AFM ;

BELAL, SF ;

HEABA, EA ;

ELKERSH, A .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (07) :851-856

[8]

Erk N, 1997, ANALUSIS, V25, P161

[9] Determination of active ingredients in the pharmaceutical formulations containing hydrochlorothiazide and its binary mixtures with benazepril hydrochloride, triamterene and cilazapril by ratio spectra derivative spectrophotometry and vierordt's method [J].

Erk, N .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 20 (1-2) :155-167

[10]

Erram S., 1992, INDIAN DRUGS BOMBAY, V29, P553

← 1 2 3 4 →