Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography

被引：92

作者：

Carlucci, G

Palumbo, G

Mazzeo, P

Quaglia, MG

机构：

[1] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67010 Coppito, Laquila, Italy

[2] Univ Aquila, Dipartimento Med Interna & Sanita Pubbl, I-67010 Coppito, Laquila, Italy

[3] Univ Roma La Sapienza, Dipartimento Studi Farmaceut, I-00185 Rome, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 01期

关键词：

HPLC; losartan potassium; hydrochlorothiazide; simultaneous determination; tablets;

D O I：

10.1016/S0731-7085(00)00268-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration lange 3.0-7.0 mu g ml(-1) for losartan and 0.5-2.0 mu g ml(-1) for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 0.08 mu g ml(-1) for losartan and 0.05 mu g ml(-1) for hydrochlorothiazide. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：185 / 189

页数：5

共 32 条

[21] DOUBLE-BLIND COMPARISON OF LOSARTAN, LISINOPRIL AND HYDROCHLOROTHIAZIDE IN HYPERTENSIVE PATIENTS WITH A PREVIOUS ANGIOTENSIN-CONVERTING ENZYME INHIBITOR-ASSOCIATED COUGH [J].