The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging

被引：153

作者：

Toescu, Emil C. ^{[1
]}

Verkhratsky, Alexei

机构：

[1] Univ Birmingham, Sch Med, Div Med Sci, Dept Physiol, Birmingham B15 2TT, W Midlands, England

[2] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

[3] Acad Sci Czech Republ, Inst Expt Med, Prague 14220 4, Czech Republic

来源：

AGING CELL | 2007年 / 6卷 / 03期

关键词：

aging; Ca2+; Ca homeostasis; cognitive decline; mitochrondia status in aging;

D O I：

10.1111/j.1474-9726.2007.00296.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a complex, multifactorial process. one of the features of normal aging of the brain is a decline in cognitive functions and much experimental attention has been devoted to understanding this process. Evidence accumulated in the last decade indicates that such functional changes are not due to gross morphological alterations, but to subtle functional modification of synaptic connectivity and intracellular signalling and metabolism. Such synaptic modifications are compatible with a normal level of activity and allow the maintenance of a certain degree of functional reserve. This is in contrast to the changes in various neurodegenerative diseases, characterized by significant neuronal loss and dramatic and irreversible functional deficit. This whole special issue has been initiated with the intention of focusing on the processes of normal brain aging. In this review, we present data that shows how subtle changes in Ca2+ homeostasis or in the state of various Ca2+-dependent processes or molecules, which occur in aging can have significant functional consequences.

引用

页码：267 / 273

页数：7

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