Stimuli-reponsive polymers and their bioconjugates

被引:2131
作者
Gil, ES [1 ]
Hudson, SM [1 ]
机构
[1] N Carolina State Univ, Fiber & Polymer Sci Program, Raleigh, NC 27695 USA
关键词
stimuli responsive; temperature responsive; pH responsive; smart polymer; intelligent polymer; hydrogels; micelles; bioconjugates; drug delivery; poly(N-isopropylacrylamide); PNIPAAm; PEO; PPO; block copolymer; LCST; polyacids; polybases;
D O I
10.1016/j.progpolymsci.2004.08.003
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Stimuli responsive polymers can provide a variety of applications for the biomedical fields. The interest in these polymers has exponentially increased due to their promising potential. Among them, temperature and pH responsive mechanisms have been considerably investigated because they are relatively convenient and effective stimuli in many applications. In this review, our main purposes are focused on temperature and pH responsive polymer systems and additionally the other stimuli-based responsive polymers will be assessed. Dozens of reviews have been recently reported to introduce the field of stimuli responsive polymers. However, most of these reviews have been focused on one specific application such as drug delivery or one specific physical form such as hydrogels. In our point of view, the whole range of applications and physical forms of stimuli responsive polymers will be elucidated, which is more helpful to design new approaches because the basic concepts and mechanisms are systematically connected. This means that any new advanced concepts and mechanisms can be utilized in a variety of other applications as well as other physical forms. Also, we will describe the classification of stimuli responsive polymers by their mechanism of response to stimuli. Moreover, this review focuses on recent approaches of molecular designs which are extremely necessary to develop more desirable and functional stimuli responsive polymers. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1173 / 1222
页数:50
相关论文
共 276 条
[51]   Thermal properties of cross-linked poly(N-isopropylacrylamide) [P(N-iPAAm)], poly(methacrylic acid) [P(MAA)], their random copolymers [P(N-iPAAm-co-MAA)], and sequential interpenetrating polymer networks (IPNs) [J].
Díez-Peña, E ;
Quijada-Garrido, I ;
Frutos, P ;
Barrales-Rienda, JM .
MACROMOLECULES, 2002, 35 (07) :2667-2675
[52]   Temperature control of biotin binding and release with a streptavidin-poly(N-isopropylacrylamide) site-specific conjugate [J].
Ding, ZL ;
Long, CJ ;
Hayashi, Y ;
Bulmus, EV ;
Hoffman, AS ;
Stayton, PS .
BIOCONJUGATE CHEMISTRY, 1999, 10 (03) :395-400
[53]   Adsorption of modified HIV-1 capsid p24 protein onto thermosensitive and cationic core-shell poly(styrene)-poly(N-isopropylacrylamide) particles [J].
Duracher, D ;
Elaïssari, A ;
Mallet, F ;
Pichot, C .
LANGMUIR, 2000, 16 (23) :9002-9008
[54]   Introducing reactive carboxyl side chains retains phase transition temperature sensitivity in N-isopropylacrylamide copolymer gels [J].
Ebara, M ;
Aoyagi, T ;
Sakai, K ;
Okano, T .
MACROMOLECULES, 2000, 33 (22) :8312-8316
[55]   Copolymerization of 2-carboxyisopropylacrylamide with N-isopropylacrylamide accelerates cell detachment from grafted surfaces by reducing temperature [J].
Ebara, M ;
Yamato, M ;
Hirose, M ;
Aoyagi, T ;
Kikuchi, A ;
Sakai, K ;
Okano, T .
BIOMACROMOLECULES, 2003, 4 (02) :344-349
[56]   pH-responsive pseudo-peptides for cell membrane disruption [J].
Eccleston, ME ;
Kuiper, M ;
Gilchrist, FM ;
Slater, NKH .
JOURNAL OF CONTROLLED RELEASE, 2000, 69 (02) :297-307
[57]   Electric field sensitive neutral polymer gels [J].
Filipcsei, G ;
Fehér, J ;
Zrínyi, M .
JOURNAL OF MOLECULAR STRUCTURE, 2000, 554 (01) :109-117
[58]   Thermoprecipitation of streptavidin via oligonucleotide-mediated self-assembly with poly (N-isopropylacrylamide) [J].
Fong, RB ;
Ding, ZL ;
Long, CJ ;
Hoffman, AS ;
Stayton, PS .
BIOCONJUGATE CHEMISTRY, 1999, 10 (05) :720-725
[59]   In vitro evaluation of pH-sensitive polymer/niosome complexes [J].
Francis, MF ;
Dhara, G ;
Winnik, FM ;
Leroux, JC .
BIOMACROMOLECULES, 2001, 2 (03) :741-749
[60]   Thermodynamically reversible addressing of a stimuli responsive fusion protein onto a patterned surface template [J].
Frey, W ;
Meyer, DE ;
Chilkoti, A .
LANGMUIR, 2003, 19 (05) :1641-1653