Single-Cell-Level Cancer Therapy Using a Hollow Optical Fiber-Based Microplasma

被引：41

作者：

Kim, Jae Young ^{[1
]}

Ballato, John ^{[2
]}

Foy, Paul ^{[2
]}

Hawkins, Thomas ^{[2
]}

Wei, Yanzhang ^{[3
]}

Li, Jinhua ^{[3
]}

Kim, Sung-O ^{[1
]}

机构：

[1] Clemson Univ, COMSET, Holcombe Dept Elect & Comp Engn, Clemson, SC 29634 USA

[2] Clemson Univ, COMSET, Sch Mat Sci & Engn, Clemson, SC 29634 USA

[3] Clemson Univ, Inst Biomed, Dept Biol Sci, Greenville, SC 29605 USA

来源：

SMALL | 2010年 / 6卷 / 14期

关键词：

cancer therapy; microplasma jets; optical fibers; plasma medicine; DIELECTRIC BARRIER DISCHARGE; PLASMA-JET;

D O I：

10.1002/smll.201000480

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A flexible microplasma jet device with a hollow-core optical fiber produces a plasma plume that is quite narrow but long enough to apply direct treatment to single-tumor cells. The microplasma induces apoptosis in murine melanoma cells in a dose-dependent manner, and under certain conditions can selectively destroy tumor cells with no harm to murine fibroblasts.

引用

页码：1474 / 1478

页数：5

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