Targeting mitochondria metabolism for cancer therapy

被引：1110

作者：

Weinberg, Samuel E. ^{[1
]}

Chandel, Navdeep S. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NATURE CHEMICAL BIOLOGY | 2015年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CELL LUNG-CANCER; GLUTAMINE-METABOLISM; OXIDATIVE-PHOSPHORYLATION; DEGENERATIVE DISEASES; ENERGY-METABOLISM; TUMOR-CELLS; METFORMIN; GROWTH; INHIBITION; GLUCOSE;

D O I：

10.1038/nchembio.1712

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer. npg (C) 2015 Nature America, Inc. All rights reserved.

引用

页码：9 / 15

页数：7

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