Peptide and protein thioester synthesis via N→S acyl transfer

被引：78

作者：

Kang, Jaskiranjit ^{[1
]}

Macmillan, Derek ^{[1
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

NATIVE CHEMICAL LIGATION; SOLID-PHASE SYNTHESIS; CPE AUTOACTIVATING UNIT; C-TERMINAL THIOESTERS; SHIFT REACTION; SPLIT INTEINS; ASSISTED THIOESTERIFICATION; GLYCOPEPTIDE THIOESTERS; AUXILIARY GROUP; CYSTEINE;

D O I：

10.1039/b925075a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptide and protein thioesters are playing an increasingly prominent role in the chemical toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In this Emerging Area we highlight recent developments in a somewhat surprising route to thioesters: selective disruption of amides, the more stable carboxylic acid derivatives.

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页码：1993 / 2002

页数：10

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