Biodegradation of high-toughness double network hydrogels as potential materials for artificial cartilage

被引:133
作者
Azuma, Chinatsu
Yasuda, Kazunori
Tanabe, Yoshie
Taniguro, Hiroko
Kanaya, Fuminori
Nakayama, Atsushi
Chen, Yong Mei
Gong, Jian Ping
Osada, Yoshihito
机构
[1] Hokkaido Univ, Sch Med, Dept Sports Med & Joint Reconstruct Surg, Kita Ku, Sapporo, Hokkaido 0608638, Japan
[2] Univ Ryukyus, Grad Sch Med, Dept Orthoped Surg, Okinawa, Japan
[3] Hokkaido Univ, Div Biol Sci, Grad Sch Sci, Sapporo, Hokkaido 0608638, Japan
关键词
D O I
10.1002/jbm.a.31043
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This study evaluated biodegradation properties of four novel high-toughness double network (DN) hydrogels as potential materials for artificial cartilage. Concerning each DN gel material, a total of 12 specimens were prepared, and 6 of the 12 specimens were examined to determine the mechanical properties without any treatments. The remaining 6 specimens were implanted into the subcutaneous tissue, using 6 mature female rabbits. At 6 weeks after implantation, the mechanical properties and the water content of the implanted specimens were measured. In the poly(2-acrylamide-2-methyl-propane sulfonic acid)/poly (N,N'-dimethyl acrylamide) DN gel, the ultimate stress and the tangent modulus were significantly increased from 3.10 and 0.20 MPa, respectively, to 5.40 and 0.37 MPa, respectively, with a significant reduction of the water content after implantation (94 to 91%). In the poly(2-acrylamide-2-methyl-propane sulfonic acid) /polyacrylamide DN gel and the cellulose /poly(dimethyl acrylamide) DN gel, the stress (11.4 and 1.90 MPa, respectively) and the modulus (0.30 and 1.70 MPa, respectively) or the water content rarely changed after implantation (90 and 85%, respectively). In the bacterial cellulose/gelatin DN gel, the ultimate stress was dramatically reduced from 4.30 to 1.98 MPa with a significant increase of the water content after implantation (78 to 86%). This study implied that these DN gels except for the cellulose/gelatin DN gel are potential materials that may meet the requirements of artificial cartilage. (c) 2006 Wiley Periodicals, Inc.
引用
收藏
页码:373 / 380
页数:8
相关论文
共 25 条
[21]   Mechanical properties of a novel PVA hydrogel in shear and unconfined compression [J].
Stammen, JA ;
Williams, S ;
Ku, DN ;
Guldberg, RE .
BIOMATERIALS, 2001, 22 (08) :799-806
[22]  
TAKAI M, 1975, POLYM J, V7, P137, DOI 10.1295/polymj.7.137
[23]   Determination of fracture energy of high strength double network hydrogels [J].
Tanaka, Y ;
Kuwabara, R ;
Na, YH ;
Kurokawa, T ;
Gong, JP ;
Osada, Y .
JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (23) :11559-11562
[24]   Biomechanical properties of high-toughness double network hydrogels [J].
Yasuda, K ;
Gong, JP ;
Katsuyama, Y ;
Nakayama, A ;
Tanabe, Y ;
Kondo, E ;
Ueno, M ;
Osada, Y .
BIOMATERIALS, 2005, 26 (21) :4468-4475
[25]  
Zheng-Qiu G, 1998, BIO-MED MATER ENG, V8, P75