Syntheses of photolabile novobiocin analogues

被引：32

作者：

Shen, G

Yu, XM

Blagg, BSJ

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

[2] Univ Kansas, Ctr Prot Struct & Funct, Lawrence, KS 66045 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期

关键词：

novobiocin; Hsp90; DNA gyrase;

D O I：

10.1016/j.bmcl.2004.09.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novobiocin was recently shown to inhibit Hsp90 through a previously unrecognized C-terminal ATP binding site. Although the N-terminal region of Hsp90 has been solved by X-ray crystallography, the C-terminal region has not. In an effort to elucidate the C-terminal binding site of Hsp90, four photolabile analogues of novobiocin were prepared. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5903 / 5906

页数：4

共 51 条

[31] DNA gyrase as a drug target
Maxwell, A
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1999, 27 (02) : 48 - 53
[32] BINDING OF BENZOQUINOID ANSAMYCINS TO P100 CORRELATES WITH THEIR ABILITY TO DEPLETE THE ERBB2 GENE-PRODUCT P185
MILLER, P
SCHNUR, RC
BARBACCI, E
MOYER, MP
MOYER, JD
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 201 (03) : 1313 - 1319
[33] Geldanamycin as a potential anti-cancer agent: Its molecular target and biochemical activity
Neckers, L
Schulte, TW
Mimnaugh, E
[J]. INVESTIGATIONAL NEW DRUGS, 1999, 17 (04) : 361 - 373
[34] Neckers Len, 2003, Current Opinion in Oncology, V15, P419, DOI 10.1097/00001622-200311000-00003
[35] NOVOBIOCIN-INDUCED ANTIPROLIFERATIVE AND DIFFERENTIATING EFFECTS IN MELANOMA-B16
NORDENBERG, J
ALBUKREK, D
HADAR, T
FUX, A
WASSERMAN, L
NOVOGRODSKY, A
SIDI, Y
[J]. BRITISH JOURNAL OF CANCER, 1992, 65 (02) : 183 - 188
[36] Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors
Peixoto, C
Laurin, P
Klich, M
Dupuis-Hamelin, C
Mauvais, P
Lassaigne, P
Bonnefoy, A
Musicki, B
[J]. TETRAHEDRON LETTERS, 2000, 41 (11) : 1741 - 1745
[37] DNA GYRASE - STRUCTURE AND FUNCTION
REECE, RJ
MAXWELL, A
[J]. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1991, 26 (3-4) : 335 - 375
[38] Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
Roe, SM
Prodromou, C
O'Brien, R
Ladbury, JE
Piper, PW
Pearl, LH
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (02) : 260 - 266
[39] Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons
Sano, M
[J]. NEUROPHARMACOLOGY, 2001, 40 (07) : 947 - 953
[40] Modulation of Akt kinase activity by binding to Hsp90
Sato, S
Fujita, N
Tsuruo, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) : 10832 - 10837

← 1 2 3 4 5 6 →