Iminium-Allenamine Cascade Catalysis: One-Pot Access to Chiral 4H-Chromenes by a Highly Enantioselective Michael-Michael Sequence

被引：134

作者：

Zhang, Xinshuai ^{[1
]}

Zhang, Shilei ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem & Biol Chem, Albuquerque, NM 87131 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 08期

基金：

美国国家科学基金会;

关键词：

alkynal; cascade reactions; enantioselectivity; Michael addition; organocatalysis; DIELS-ALDER REACTION; ASYMMETRIC-SYNTHESIS; NUCLEOPHILIC-ADDITION; FACILE CONSTRUCTION; ALLENES; PALLADIUM; ALCOHOLS; ESTERS; 2-AMINO-4H-CHROMENES; CYCLOADDITION;

D O I：

10.1002/anie.200906050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical Equation Presented Taking the Michael-Michael: A cascade Michael-Michael reaction of aryl or alkyl alkynals, involving an unprecedented iminium - allenamine sequence, is efficiently catalyzed by a chiral diphenylprolinol TBDMS ether, and affords highly functionalized 4H-chromenes in high yields. TBDMS = tert-butyldimethylsilyl. © 2010 Wiley-VCH Verlag GmbH &. Co. KGaA,.

引用

页码：1481 / 1484

页数：4

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