Hydroaminomethylation with novel rhodium-carbene complexes: An efficient catalytic approach to pharmaceuticals

被引：72

作者：

Ahmed, Moballigh ^{[1
]}

Buch, Cathleen ^{[1
]}

Routaboul, Lucie ^{[1
]}

Jackstell, Ralf ^{[1
]}

Klein, Holger ^{[1
]}

Spannenberg, Anke ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse EV, D-18059 Rostock, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 05期

关键词：

amines; carbenes; carbonylation; hydroaminomethylation; pharmaceuticals; rhodium;

D O I：

10.1002/chem.200601155

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starting from [jRh(cod)Cl)21 and 1,3-dimesitylimidazole-2-ylidenes the novel [RhCl(cod)(carbene)] complexes 1-5 have been synthesized, characterized, and tested in the hydroaminomethylation of aromatic olefins. The influence of different ligands and reaction parameters on the catalytic activitywas investigated in detail applying 1,1diphenylethylene and piperidine as a model system. The scope and limitations of the novel catalysts is shown in the preparation of 16 biologically active 1-amino-3,3-diarylpropenes. In general, high chemo- and regioselectivity as well as good yields of the desired products were achieved.

引用

页码：1594 / 1601

页数：8

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