Functionalized gold nanoparticles for drug delivery

被引:385
作者
Han, Gang [1 ]
Ghosh, Partha [1 ]
Rotello, Vincent M. [1 ]
机构
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
关键词
delivery; DNA; drug; gene; glutathione; gold; nanoparticles; photochemistry; release;
D O I
10.2217/17435889.2.1.113
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Functionalized gold nanoparticles represent highly attractive and promising candidates in the applications of drug delivery owing to their unique dimensions, tunable functionalities on the surface and controllable drug release. This review illustrates the recent advances in the field of drug delivery using gold nanoparticles as carriers for therapeutic agents.
引用
收藏
页码:113 / 123
页数:11
相关论文
共 40 条
  • [21] Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters
    McIntosh, CM
    Esposito, EA
    Boal, AK
    Simard, JM
    Martin, CT
    Rotello, VM
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (31) : 7626 - 7629
  • [22] HUMAN GENE-THERAPY COMES OF AGE
    MILLER, AD
    [J]. NATURE, 1992, 357 (6378) : 455 - 460
  • [23] Colloidal gold: A novel nanoparticle vector for tumor directed drug delivery
    Paciotti, GF
    Myer, L
    Weinreich, D
    Goia, D
    Pavel, N
    McLaughlin, RE
    Tamarkin, L
    [J]. DRUG DELIVERY, 2004, 11 (03) : 169 - 183
  • [24] Colloidal gold nanoparticles: A novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors
    Paciotti, Giulio F.
    Kingston, David G. I.
    Tamarkin, Lawrence
    [J]. DRUG DEVELOPMENT RESEARCH, 2006, 67 (01) : 47 - 54
  • [25] Acid- and salt-triggered multifunctional poly(propylene imine) dendrimer as a prospective drug delivery system
    Paleos, CM
    Tsiourvas, D
    Sideratou, Z
    Tziveleka, L
    [J]. BIOMACROMOLECULES, 2004, 5 (02) : 524 - 529
  • [26] Rosi NL, 2006, SCIENCE, V312, P1027, DOI 10.1126/science.1125559
  • [27] Nanostructures in biodiagnostics
    Rosi, NL
    Mirkin, CA
    [J]. CHEMICAL REVIEWS, 2005, 105 (04) : 1547 - 1562
  • [28] Synthesis of nitric oxide-releasing gold nanoparticles
    Rothrock, AR
    Donkers, RL
    Schoenfisch, MH
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (26) : 9362 - 9363
  • [29] Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
    Saito, G
    Swanson, JA
    Lee, KD
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (02) : 199 - 215
  • [30] Multifunctional nanorods for gene delivery
    Salem, AK
    Searson, PC
    Leong, KW
    [J]. NATURE MATERIALS, 2003, 2 (10) : 668 - 671