Developing an anion host for lipid A binding and antibacterial activity

被引：34

作者：

Henderson, Luke C. ^{[1
]}

Li, Jian ^{[2
]}

Nation, Roger L. ^{[2
]}

Velkov, Tony ^{[2
,3
]}

Pfeffer, Frederick M. ^{[1
]}

机构：

[1] Deakin Univ, Sch Life & Environm Sci, Geelong, Vic 3217, Australia

[2] Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia

[3] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 18期

关键词：

ANTIENDOTOXIN AGENTS; IN-VITRO; LIPOPOLYSACCHARIDE; RECOGNITION; POLYMYXIN; COLISTIN; GUANIDINIUM; SELECTIVITY; TRANSPORT;

D O I：

10.1039/b925135a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New structural amphiphiles 2a and 2b bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.

引用

页码：3197 / 3199

页数：3

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