Hydrogen iodide-promoted reduction of β-chlorovinamidinium salts

被引：13

作者：

Davies, IW ^{[1
]}

Taylor, M ^{[1
]}

Hughes, D ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 21期

关键词：

D O I：

10.1021/ol006497z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] HI cleanly reduced chlorovinamidinium salts to the vinamidinium salt in essentially quantitative assay yield and 55-85% isolated yield following recrystallization. The reaction proceeds via protonation of the beta-carbon atom of the vinamidinium and dechlorination via the formation of I-CI.

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页码：3385 / 3387

页数：3

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