Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour

被引:20
作者
Brewer, Warrick J.
Wood, Stephen J.
Pantelis, Christos
Berger, Gregor E.
Copolov, David L.
McGorry, Patrick D.
机构
[1] ORYGEN, Res Ctr, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Parkville, Vic 3052, Australia
[3] Monash Univ, Melbourne, Vic 3004, Australia
[4] Brain Res Inst, Melbourne, Vic, Australia
[5] Univ Melbourne, Howard Florey Inst, Parkville, Vic 3052, Australia
基金
英国医学研究理事会;
关键词
hexenoic acid; metabolism; biological marker;
D O I
10.1016/j.psychres.2006.03.005
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
There is some evidence for an unusual body odour in schizophrenia that has been linked to a hexenoic acid derivative (trans-3-methyl-2-hexenoic acid; MHA). Poor body odour has been linked to increased negative symptoms and reduced olfactory identification ability. However, the relationship between these findings and MHA, including olfactory sensitivity for MHA, has not been examined. Olfactory sensitivity thresholds were assessed for MHA and n-butyl-alcohol (NBA), in normal controls (CTL; n=24), patients with chronic schizophrenia (CHR; n=32) and a first-episode psychosis cohort (FE; n=31). In addition, forced choice detection of the pheromonal steroids 5-alpha-androst-16-en-3 -one, androsterone-sulphate and estrone-3-sulphate was performed along with a measure of olfactory identification. CHR patients had significantly reduced sensitivity to MHA, but not NBA, compared to FE and CTL subjects. While sensitivity to pheromones was not different between the groups, CHR patients who could not detect them also showed poorer sensitivity to MHA. Further, the CHR group showed a significant association between reduced MHA sensitivity and greater levels of disorganised and negative symptoms. No relationships between identification and sensitivity for any substance were found. Our findings are the first to report reduced sensitivity for MHA in chronic schizophrenia patients, in the absence of similar impairment for more traditionally used substances. This may be linked to olfactory habituation effects, abnormal chemical processing or a genetic predisposition. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:97 / 104
页数:8
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