First synthesis of naturally occurring (±)-epi-conocarpan

被引：37

作者：

Zheng, SL ^{[2
]}

Yu, WY

Xu, MX

Che, CM

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Sichuan Univ, W China Sch Pharm, Chengdu 610041, Peoples R China

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 07期

关键词：

(+/-)-epi-conocarpan; cis-2,3-dihydrobenzofuran; intramolecular C-H insertion; ruthenium(II) porphyrin;

D O I：

10.1016/S0040-4039(02)02860-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+/-)-epi-Conocarpan 1 was synthesized via the key intermediate 5-bromo-cis-2-(4-methoxyphenyl)-3-methyl-2,3-dihydrobenzofuran 6 which was synthesized by a ruthenium(II) porphyrin-catalyzed intramolecular C-H insertion reaction using aryl tosylhydrazone salt 5 as the carbene source, starting from the commercially available 5-bromo-2-hydroxyacetophenone. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1445 / 1447

页数：3

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