Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression

被引：220

作者：

Christofori, G ^{[1
]}

机构：

[1] Univ Basel, Inst Biochem & Genet, Dept Clin Biol Sci, CH-4051 Basel, Switzerland

来源：

EMBO JOURNAL | 2003年 / 22卷 / 10期

关键词：

cadherin; cell adhesion; integrin; metastasis; signalling;

D O I：

10.1093/emboj/cdg228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Changes in cell-cell and cell-matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.

引用

页码：2318 / 2323

页数：6

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