Iminosugars and relatives as antiviral and potential anti-infective agents

被引：206

作者：

Greimel, P ^{[1
]}

Spreitz, J ^{[1
]}

Stütz, AE ^{[1
]}

Wrodnigg, TM ^{[1
]}

机构：

[1] Graz Univ, Inst Organ Chem, Glycogrp, A-8010 Graz, Austria

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 05期

关键词：

iminosugar; iminoalditol; antiinfective; antiviral; antibacterial; antifungal; antiprotozoan;

D O I：

10.2174/1568026033452456

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from antidiabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as-in selected cases-anti-infective properties. The latter will be the focus of the following survey.

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页码：513 / 523

页数：11

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