Inhibitors of bacterial tyrosyl tRNA synthetase: Synthesis of four stereoisomeric analogues of the natural product SB-219383

被引：32

作者：

Berge, JM ^{[1
]}

Copley, RCB ^{[1
]}

Eggleston, DS ^{[1
]}

Hamprecht, DW ^{[1
]}

Jarvest, RL ^{[1
]}

Mensah, LM ^{[1
]}

O'Hanlon, PJ ^{[1
]}

Pope, AJ ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(00)00348-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic analogues of the microbial metabolite SB-219383 have been synthesised with defined stereochemistry. Densely functionalised hydroxylamine containing amino acids were prepared by the addition of a glycine anion equivalent to sugar-derived cyclic nitrones. One of four stereoisomeric dipeptides incorporating these novel amino acids was found to be a potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, suggesting analogous stereochemistry of the natural product. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1811 / 1814

页数：4

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