O-demethylation and sulfation of 7-methoxylated flavanones by Cunninghamella elegans

被引：62

作者：

Ibrahim, ARS ^{[1
]}

Galal, AM

Ahmed, MS

Mossa, GS

机构：

[1] Tanta Univ, Coll Pharm, Dept Pharmacognosy, Tanta 8130, Egypt

[2] Cairo Univ, Coll Pharm, Dept Pharmacognosy, Cairo 11562, Egypt

[3] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 02期

关键词：

7-methoxyflavanone; sulfation; Cunninghamella elegans; NMR; ESI-MS;

D O I：

10.1248/cpb.51.203

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Metabolism of 7-O-methylnaringenin (sakuranetin) by Cunninghamella elegans NRRL 1392 yielded naringenin and naringenin-4'-sulfate. C elegans also converted 5,3',4'-trihydroxy-7-methoxyflavanone into eriodictyol-4'-sulfate. Furthermore, incubation of 5,4'-dihydroxy-7,3'-dimethoxyflavanone with the same fungus gave homoeriodictyol (5,7,4'-trihydroxy-3'-methoxyflavanone) and homoeriodicytol-7-sulfate. The structures of the new metabolites were established by spectral analysis including 2D-NMR, HR-ESI-FT-MS beside hydrolysis by acid.

引用

页码：203 / 206

页数：4

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