Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants

被引:117
作者
Viljanen, M
Kuitunen, M
Haahtela, T
Juntunen-Backman, K
Korpela, R
Savilahti, E
机构
[1] Univ Helsinki, Skin & Allergy Hosp, Helsinki 00250, Finland
[2] Valio Res & Dev, Helsinki, Finland
[3] Univ Helsinki, Inst Biomed Pharmacol, Helsinki, Finland
[4] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland
关键词
atopic dermatitis; infants; inflammation; intestine; Lactobacillus GG; probiotic; treatment;
D O I
10.1111/j.1399-3038.2005.00224.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Probiotic bacteria are proposed to alleviate intestinal inflammation in infants with atopic eczema/dermatitis syndrome (AEDS) and food allergy. In such infants we investigated effects of probiotic bacteria on faecal IgA, and on the intestinal inflammation markers tumour necrosis factor-alpha (TNF-alpha), alpha(1)-antitrypsin (AT), and eosinophil cationic protein (ECP). A total of 230 infants with AEDS and suspected cow's milk allergy (CMA) received in a randomized double-blinded manner, concomitant with elimination diet, Lactobacillus GG (LGG), a mixture of four probiotic strains (MIX), or placebo for 4 wk. Four weeks after treatment, CMA was diagnosed with a double-blind placebo-controlled milk challenge. Faecal samples of 102 infants, randomly chosen for analysis, were collected before treatment, after 4-wk treatment, and on the first day of milk challenge. After treatment, IgA levels tended to be higher in probiotic groups than in the placebo group (LGG vs. placebo, p = 0.064; MIX vs. placebo, p = 0.064), and AT decreased in the LGG group, but not in other treatment groups. After challenge in IgE-associated CMA infants, faecal IgA was higher for LGG than for placebo (p = 0.014), and TNF-alpha was lower for LGG than for placebo, but non-significantly (p = 0.111). In conclusion, 4-wk treatment with LGG may alleviate intestinal inflammation in infants with AEDS and CMA.
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页码:65 / 71
页数:7
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