Mycophenolic acid: A one hundred year odyssey from antibiotic to immunosuppressant

被引：248

作者：

Bentley, R ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

来源：

CHEMICAL REVIEWS | 2000年 / 100卷 / 10期

关键词：

D O I：

10.1021/cr990097b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mycophenolate mofetil (MMF) from Gosio's mycophenolic acid (MPA) undergo rapid and complete absorption, and completely metabolized to pharmacologically inactive and stable phenolic glucuronide. The compound exhibits antibacterial, antifungal, antitumor, and antiviral properties. The properties help for increasing the susceptibility of animals to fungal infections and preventing various disorders. It is widely used as an immunosuppressant in kidney, heart, and liver transplantation.

引用

页码：3801 / 3825

页数：25

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