Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells

被引：230

作者：

Ankamwar, B. ^{[1
]}

Lai, T. C. ^{[2
]}

Huang, J. H. ^{[1
]}

Liu, R. S. ^{[1
]}

Hsiao, M. ^{[2
]}

Chen, C. H. ^{[2
]}

Hwu, Y. K. ^{[3
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[3] Acad Sinica, Inst Phys, Taipei 115, Taiwan

来源：

NANOTECHNOLOGY | 2010年 / 21卷 / 07期

关键词：

IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; MAGNETITE NANOPARTICLES; CELLULAR UPTAKE; VIVO TRACKING; DEXTRAN; NANOTECHNOLOGY; HYPERTHERMIA; TOXICITY; SIZE;

D O I：

10.1088/0957-4484/21/7/075102

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In order to reveal the biocompatibility of Fe3O4 nanoparticles and bipolar surfactant tetramethylammonium 11-aminoundecanoate cytotoxicity tests were performed as a function of concentration from low (0.1 mu g ml(-1)) to higher concentration (100 mu g ml(-1)) using various human glia, human breast cancer and normal cell lines. Cytotoxicity tests for human glia (D54MG, G9T, SF126, U87, U251, U373), human breast cancer (MB157, SKBR3, T47D) and normal (H184B5F5/M10, WI-38, SVGp12) cell lines exhibited almost nontoxicity and reveal biocompatibility of Fe3O4 nanoparticles in the concentration range of 0.1-10 mu g ml(-1), while accountable cytotoxicity can be seen at 100 mu g ml(-1). The results of our studies suggest that Fe3O4 nanoparticles coated with bipolar surfactant tetramethylammonium 11-aminoundecanoate are biocompatible and promising for bio-applications such as drug delivery, magnetic resonance imaging and magnetic hyperthermia.

引用

页数：9

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