The role of neuroinflammation on the pathogenesis of Parkinson's disease

被引：131

作者：

Chung, Young Cheul ^{[1
,2
]}

Ko, Hyuk Wan ^{[1
]}

Bok, Eugene ^{[1
,2
]}

Park, Eun Soo ^{[1
,2
]}

Huh, Sue Hee ^{[1
,2
]}

Nam, Jin Han ^{[1
]}

Jin, Byung Kwan ^{[1
]}

机构：

[1] Kyung Hee Univ, Sch Med, Neurodegenerat Control Res Ctr, Dept Biochem & Mol Biol, Seoul, South Korea

[2] Ajou Univ, Sch Med, Div Cell Transformat & Restorat, Grad Program Neurosci, Suwon 441749, South Korea

来源：

BMB REPORTS | 2010年 / 43卷 / 04期

关键词：

Astrocyte; BBB leakage; Infiltration of peripheral immune cells; Microglia; Parkinson's disease; BLOOD-BRAIN-BARRIER; NITRIC-OXIDE SYNTHASE; PROTECTS DOPAMINERGIC-NEURONS; INDUCED MICROGLIAL ACTIVATION; ALPHA TNF-ALPHA; IN-VIVO; SUBSTANTIA-NIGRA; NADPH OXIDASE; MOUSE MODEL; CEREBROSPINAL-FLUID;

D O I：

10.5483/BMBRep.2010.43.4.225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's Disease (PD) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Although the causative factors of PD remain elusive, many studies on PD animal models or humans suggest that glial activation along with neuroinflammatory processes contribute to the initiation or progression of PD. Additionally, several groups have proposed that dysfunction of the blood-brain barrier (BBB) combined with infiltration of peripheral immune cells play important roles in the degeneration of DA neurons. However, these neuroinflammatory events have only been investigated separately, and the issue of whether these phenomena are neuroprotective or neurotoxic remains controversial. We here review the current knowledge regarding the functions of these neuroinflammatory processes in the brain. Finally, we describe therapeutic strategies for the regulation of neuroinflammation with the goal of improving the symptoms of PD. [BMB reports 2010; 43(4): 225-232]

引用

页码：225 / 232

页数：8

共 80 条

[71] ACTIVITIES OF BUTYRYLCHOLINESTERASE AND CARBONIC-ANHYDRASE, RATE OF ANAEROBIC GLYCOLYSIS, AND QUESTION OF A CONSTANT DENSITY OF GLIAL CELLS IN CEREBRAL CORTICES OF VARIOUS MAMMALIAN SPECIES FROM MOUSE TO WHALE [J].