A convenient and versatile method for the synthesis of protected guanidines

被引：38

作者：

Guo, ZX

Cammidge, AN ^{[1
]}

Horwell, DC

机构：

[1] Univ E Anglia, Sch Chem Sci, Norwich NR4 7TJ, Norfolk, England

[2] Cambridge Univ Forvie Site, Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 16期

关键词：

D O I：

10.1080/00397910008087443

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aromatic, aliphatic and sterically hindered amines react smoothly with commercially available N,N'-bis-BOC-S-methylisothiourea 2 in the presence of mercury chloride to give the protected guanidine in good yield. It is particularly noteworthy that 2 can also be employed in a straightforward, two-step synthesis of monoaryl internal guanidines.

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页码：2933 / 2943

页数：11

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