On indium(III) chloride-catalyzed aldol reactions of silyl enol ethers with aldehydes in water

被引：48

作者：

Kobayashi, S ^{[1
]}

Busujima, T

Nagayama, S

机构：

[1] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 162, Japan

[2] Japan Sci & Technol Corp, CREST, Shinjuku Ku, Tokyo 162, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(98)00033-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Contrary to previous reports, it was found that hydrolysis of silyl enol ethers is superior to the desired condensation in InCl3-catalyzed aldol reactions of silyl enol ethers with aldehydes in water. The reactions were found to proceed in certain amounts in the presence of a catalytic amount of a Lewis acid under neat (solvent-free) conditions, while substrate limitation was observed in these reactions. Use of InCl3 as a Lewis acid in aldol reactions in micellar systems is also reported. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1579 / 1582

页数：4

共 16 条

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