On indium(III) chloride-catalyzed aldol reactions of silyl enol ethers with aldehydes in water

被引:48
作者
Kobayashi, S [1 ]
Busujima, T
Nagayama, S
机构
[1] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 162, Japan
[2] Japan Sci & Technol Corp, CREST, Shinjuku Ku, Tokyo 162, Japan
关键词
D O I
10.1016/S0040-4039(98)00033-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Contrary to previous reports, it was found that hydrolysis of silyl enol ethers is superior to the desired condensation in InCl3-catalyzed aldol reactions of silyl enol ethers with aldehydes in water. The reactions were found to proceed in certain amounts in the presence of a catalytic amount of a Lewis acid under neat (solvent-free) conditions, while substrate limitation was observed in these reactions. Use of InCl3 as a Lewis acid in aldol reactions in micellar systems is also reported. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:1579 / 1582
页数:4
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