Rapid and highly selective copper-free Sonogashira coupling in high-pressure, high-temperature water in a microfluidic system

被引：80

作者：

Kawanami, Hajime ^{[1
]}

Matsushima, Keiichiro ^{[1
]}

Sato, Masahiro ^{[1
]}

Ikushima, Yutaka ^{[1
]}

机构：

[1] Natl Inst Adv Sci & Technol, Res Ctr Compact Chem Proc, Miyagino Ku, Sendai, Miyagi 9838551, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 27期

关键词：

D O I：

10.1002/anie.200700611

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All in a whirl: A reaction system based on "step-by-step rapid mixing and heating" with high-pressure, high-temperature water has been applied to an extremely efficient Sonogashira coupling (see picture). No organic solvents or ligands for the Pd catalyst were required. R = Me, OMe, NH2, OH, CF3. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5129 / 5132

页数：4

共 58 条

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