The orphan nuclear receptor Rev-erbα:: a transcriptional link between circadian rhythmicity and cardiometabolic disease

被引:34
作者
Fontaine, Coralie [1 ]
Staels, Bart [1 ]
机构
[1] Univ Lille 2, Inst Pasteur, INSERM, U545, F-59019 Lille, France
关键词
cardiovascular disease; circadian rhythm; metabolic syndrome; nuclear receptors; Rev-erb alpha;
D O I
10.1097/MOL.0b013e3280464ef6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Purpose of review This review focuses on recent advances on the role of the orphan nuclear receptor Rev-erb alpha, a transcription factor participating in the control of circadian rhythm and cardiometabolic disease. Recent findings Circadian patterns of cardiovascular vulnerability are well documented, with a peak incidence of cardiovascular events in the morning. Recent studies have outlined the importance of the Clock genes in the development of metabolic disorders predisposing to atherosclerosis. Rev-erba is a nuclear receptor that regulates hepatic and adipose lipid metabolism as well as vascular inflammation. Moreover, Rev-erb alpha is also part of the clock transcription machinery and the target of some clock transcription factors. Summary These findings identify Rev-erb alpha as a modulator of cardiovascular risk factors and as a determinant of the circadian regulation of metabolic pathways. Moreover, Rev-erb alpha crosstalks with other nuclear receptors which influence atherosclerosis susceptibility. Rev-erbot may thus serve to integrate metabolic and circadian signals.
引用
收藏
页码:141 / 146
页数:6
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