The renin phenotype: roles and regulation in the kidney

被引：18

作者：

Lopez, Maria L. S. Sequeira ^{[1
]}

Gomez, R. Ariel ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Pediat, Charlottesville, VA 22908 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2010年 / 19卷 / 04期

基金：

美国国家卫生研究院;

关键词：

cell identity; cell memory; cyclic AMP; microRNAs; plasticity; ACTIVATED-RECEPTOR-GAMMA; NECROSIS-FACTOR-ALPHA; GENE-EXPRESSION; JUXTAGLOMERULAR CELLS; BLOOD-PRESSURE; RESPONSIVE ELEMENT; MICE; TRANSCRIPTION; CONNEXIN40; RECRUITMENT;

D O I：

10.1097/MNH.0b013e32833aff32

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Renin cells are fundamental for the control of blood pressure, fluid electrolyte homeostasis and kidney development. This review discusses recent discoveries regarding the mechanisms that control the identity and fate of renin cells and their role in the maintenance of kidney architecture and function. Recent findings It is now established that cyclic AMP is a crucial factor for the regulation of the renin phenotype. Furthermore, additional factors such as microRNAs and gap junctions have recently emerged as key regulators for the maintenance and proper functioning of renin cells. Summary Experiments described in this review will hopefully raise new questions regarding the mechanisms that control the identity, plasticity and function of renin cells.

引用

页码：366 / 371

页数：6

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