Formation of an aza-nickelacycle by reaction of an imine and an alkyne with nickel(0): Oxidative cyclization, insertion, and reductive elimination

被引：85

作者：

Ogoshi, Sensuke ^{[1
]}

Ikeda, Haruo ^{[1
]}

Kurosawa, Hideo ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Osaka, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 26期

关键词：

alkynes; cycloaddition; imines; metallacycles; nickel;

D O I：

10.1002/anie.200700688

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Cyclize, add, reduce: The oxidative cyclization of an imine and an alkyne with nickel(0) followed by the insertion of a second alkyne gives a seven-membered aza-nickelacycle (see scheme). Subsequent reductive elimination yields a 1,2-dihydropyridine. This sequential reaction process is expanded to a one-step nickel-catalyzed [2+2+2] cycloaddition of two alkynes and an imine. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4930 / 4932

页数：3

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