Catalytic asymmetric reductive coupling of alkynes and aldehydes:: Enantioselective synthesis of allylic alcohols and α-hydroxy ketones

被引：239

作者：

Miller, KM ^{[1
]}

Huang, WS ^{[1
]}

Jamison, TF ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 12期

关键词：

D O I：

10.1021/ja034366y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective method for catalytic reductive coupling of alkynes and aldehydes is described. Allylic alcohols are afforded with complete E/Z selectivity, generally >95:5 regioselectivity, and in up to 96% ee. In conjunction with ozonolysis, this process is complementary to existing methods of enantioselective α-hydroxy ketone synthesis. Copyright © 2003 American Chemical Society.

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收藏

页码：3442 / 3443

页数：2

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