Eight-membered ring construction by [4+2+2] annulation involving β-carbon elimination

被引：145

作者：

Murakami, M ^{[1
]}

Ashida, S ^{[1
]}

Matsuda, T ^{[1
]}

机构：

[1] Kyoto Univ, Dept Synth Chem & Biol Chem, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 07期

关键词：

D O I：

10.1021/ja0552895

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclobutanones underwent a formal [4 + 2 + 2] annulation reaction with 1,6- and 1,7-diynes in the presence of nickel(0) catalysts to provide bicyclic eight-membered ring ketones. The annulation reaction proceeds through a ring-expansion of oxanickelacycloheptadiene via β-carbon elimination to form a nine-membered nickelacycle. This reaction employing cyclobutanones as a C4 unit constructs cyclooctadienone cores in one synthetic step. Copyright © 2006 American Chemical Society.

引用

页码：2166 / 2167

页数：2

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